Stilnox Brand

Zolpidem tartrate.

Each scored film-coated tablet contains: Zolpidem tartrate 10 mg.

Pharmacotherapeutic group: Hypnotics and sedatives. ATC code: N05CF02 (N: Central Nervous System).
Pharmacology: Pharmacodynamics: Zolpidem is a hypnotic imidazopyridine related to benzodiazepines with pharmacodynamic effects that are qualitatively similar to that of other compounds in the same class, i.e.: muscle relaxant, anxiolytic, sedating, hypnotic, anticonvulsant, amnesic.
Experimental studies have demonstrated a sedative effect at doses lower than those required to obtain anticonvulsant, muscle-relaxant or anxiolytic effects.
These effects are related to a specific agonist action on a central receptor belonging to the “GABA-OMEGA” macromolecular receptor complex, also known as BZ1 and BZ2, modulating the opening of the chloride ion channel. Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

Zolpidem preferentially binds to the omega-1 receptor subtype (or BZ1).
In man, zolpidem decreases sleep latency, reduces the number of nocturnal awakenings, and increases total sleep duration and sleep quality. These effects are associated with a characteristic EEG profile, different from that of benzodiazepines. Studies recording night-time sleep have shown that zolpidem prolongs both stage II sleep and deep sleep stages (III and IV). At the recommended dose, zolpidem has no influence on total paradoxical sleep duration (REM).
In randomized trials, zolpidem was shown to be effective only at the 10 mg dose.
In a randomized double-blind study in 462 healthy volunteers under 65 years of age with transient insomnia, sleep latency was decreased by 10 minutes in the zolpidem 10 mg group and by 3 minutes in the 5 mg group compared to placebo. Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

In a randomized double-blind study in 114 patients under 65 years of age with chronic insomnia, mean sleep latency was decreased by 30 minutes in the zolpidem 10 mg group and by 15 minutes in the 5 mg group compared to placebo.
In some patients, a dose of 5 mg may prove to be effective.
Children and adolescents: Randomized placebo-controlled study in 201 children and adolescents aged 6-17 years with insomnia associated with Attention Deficit Hyperactivity Disorder (ADHD) failed to demonstrate efficacy of zolpidem 0.25 mg/kg/day (with a maximum of 10 mg/day) compared to placebo. Psychiatric and neurological disorders were the adverse events most frequently observed in patients treated with zolpidem compared to placebo and included dizziness (23.5% versus 1.5%), headache (12.5% versus 9.2%), and hallucinations (7.4% versus 0%). Where can I Buy Stilnox zolpidem for sale online in USA, USWhere can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

Consequently, and in the absence of any new studies, zolpidem must not be prescribed in this population. (See Dosage & Administration.)
Pharmacokinetics: Absorption: After oral administration, the bioavailability of zolpidem is approximately 70% and peak plasma concentrations are reached in 0.5 to 3 hours.
Distribution: The pharmacokinetic pattern of the drug is linear at therapeutic doses. Zolpidem is approximately 92% bound to plasma proteins. The volume of distribution in adults is 0.54 ± 0.02 l/kg.
Metabolism and elimination: Zolpidem is eliminated as inactive metabolites (via liver metabolism), primarily in the urine (approximately 60%) and feces (approximately 40%). It does not have a liver enzyme-inducing effect.
Mean plasma elimination half-life is 2.4 hours (0.7 to 3.5 hours). Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

At-risk populations: Liver clearance is reduced in elderly patients. Peak plasma concentrations are approximately 50% higher in this population and the half-life is not significantly prolonged (mean of 3 hours). The volume of distribution is reduced to 0.34 ± 0.05 l/kg.
Renal clearance is moderately decreased in patients with kidney failure, regardless of whether they are dialyzed or not. The other kinetic parameters remain unchanged. Zolpidem is not dialyzable.
In patients with liver failure, bioavailability of zolpidem is increased. Clearance is substantially reduced and elimination half-life prolonged (approximately 10 hours).

Use of zolpidem is limited to the treatment of severe sleep disorders in adults with: Transient insomnia, Short-term insomnia.

Dose: The treatment should be taken as a single dose and not be re-administered during the same night.
The recommended daily dose for adults is 10 mg, to be taken immediately at bedtime.
Treatment should always be initiated at the lowest effective dose and the maximum dosage must not exceed 10 mg. Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

Elderly or debilitated subjects: As elderly or debilitated patients are especially sensitive to the effects of zolpidem, the recommended dose in this population is 5 mg (i.e. half a tablet).
Liver failure: As the clearance and metabolism of zolpidem are reduced in liver failure, treatment should be initiated at 5 mg per day in these patients, with particular caution being exercised in elderly patients.
Under no circumstances should the daily dose exceed 10 mg.
Stilnox may be prescribed for use continuously or as required, depending on the signs and symptoms.
Paediatric population: The safety and efficacy of zolpidem in children and adolescents under 18 years of age have not been demonstrated. Therefore, use of zolpidem is not recommended in this population. The available evidence from placebo-controlled clinical trials is presented in Pharmacology: Pharmacodynamics under Actions. Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada

Treatment duration: The duration of treatment should be as short as possible, from a few days to four weeks, including the tapering off period (see Warnings and Precautions).
The duration of treatment must be explained to the patient: 2 to 5 days for transient insomnia (when traveling, for example); 2 to 3 weeks for short-term insomnia (following a serious event, for example).
Very short-term treatments do not require discontinuation tapering-off period.
In some cases, it may be necessary to extend treatment beyond the recommended durations. This requires detailed and repeated reassessment of the patient’s condition. Where can I Buy Stilnox zolpidem for sale online in USA, UK Australia Canada